牙髓干细胞的生物学特性及其在角膜和视网膜疾病治疗中应用的研究进展
Research progress in biological characteristics of dental pulp stem cells and their applications in treatment of corneal and retinal diseases
刘翔宇 1张梦迪 1王霁雪 2徐春玲1
作者信息
- 1. 吉林大学第二医院眼科,吉林 长春 130041
- 2. 白城医学高等专科学校眼视光学院,吉林 白城 137000
- 折叠
摘要
牙髓干细胞(DPSCs)是一类具有广泛应用潜力的间充质干细胞.DPSCs因其多向分化潜能和易获取的特点成为眼科领域研究的热点.近年来,DPSCs在角膜上皮损伤和视网膜退行性病变的治疗中表现出潜在的临床应用前景.DPSCs可以通过分化为角膜上皮细胞和抑制M1巨噬细胞,促进角膜上皮再生和重建.此外,DPSCs也可以分化为视网膜光感受器样细胞和视网膜神经节样细胞,替换原有视神经元,分泌神经营养因子介导损伤修复,促进视网膜的再生,改善视网膜原有功能.现系统地回顾近年来国内外相关文献,就DPSCs的生物学特性及其在角膜和视网膜疾病治疗中应用的研究进展进行综述,以期为DPSCs在转化医学和眼科相关疾病治疗中应用的研究提供思路及策略.
Abstract
Dental pulp stem cells(DPSCs)are a type of mesenchymal stem cells with broad application potential.Due to their multipotent differentiation capabilities and ease of access,DPSCs have become a focus of research in the field of ophthalmology.In recent years,DPSCs have shown the potential clinical applications in the treatment of corneal epithelial injuries and retinal degenerative diseases.DPSCs can promote the corneal epithelial regeneration and reconstruction by differentiating into the corneal epithelial cells and inhibiting the M1 macrophages.Additionally,DPSCs can differentiate into the retinal photoreceptor-like cells and retinal ganglion-like cells,replace original retinal neurons,secrete neurotrophic factors to mediate injury repair,promote retinal regeneration,and improve the original function of the retina.This article systematically reviews the relevant domestic and international literatures in recent years,discussing the biological characteristics of DPSCs and the research progress in their applieation in the treatment of corneal and retinal diseases,with the aim of providing insights and strategies for the study of DPSCs in translational medicine and ophthalmic-related diseases.
关键词
牙髓干细胞/眼/角膜/视网膜/旁分泌Key words
Dental pulp stem cells/Eye/Cornea/Retina/Paracrine引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据