急性髓系白血病中表观遗传学的研究进展
Progress of epigenetics in acute myeloid leukemia
林丽蔓 1李登举1
作者信息
- 1. 华中科技大学同济医学院附属同济医院血液内科,武汉 430030
- 折叠
摘要
急性髓系白血病(AML)是某种基因改变导致的基因功能不可逆性改变,造成白血病细胞异常增殖、分化障碍、凋亡异常等,从而引起白血病的发生、发展.表观遗传学是指所研究的基因在序列不发生改变的情况下,却发生了可遗传基因表达的改变.目前有大量研究数据表明,AML发病与表观遗传学的调控密切相关.表观遗传修饰在细胞代谢、免疫微环境和免疫应答中的调控作用越来越受到重视,文章将系统阐述表观遗传学在AML细胞代谢、免疫微环境和免疫应答中的调控作用,以及针对性干预治疗措施的研究进展.
Abstract
Acute myeloid leukemia (AML) is considered to be an irreversible change of gene function caused by certain genetic changes, resulting in abnormal proliferation, differentiation disorder, and abnormal apoptosis of leukemia cells, leading to the occurrence and development of leukemia. Epigenetics refers to the change of heritable gene expression but the gene does not change in sequence. A large number of studies have shown that the pathogenesis of AML is closely related to the regulation of epigenetics. The regulation of epigenetic modification in the cellular metabolism, immune microenvironment and immune response of AML has been received increasing attention. This review will describe the regulation of epigenetics in the cellular metabolism, immune microenvironment and immune response of AML and the advances in the targeted intervention measures.
关键词
白血病,髓样,急性/表观遗传学,突变/免疫组织化学Key words
Leukemia,myeloid,acute/Epigenetic,mutation/Immunohistochemistry引用本文复制引用
基金项目
国家自然科学基金(81770168)
Fund program: National Natural Science Foundation of China(81770168)
出版年
2019
NETL
NSTL
维普
万方数据