Research Progress on Molecular Mechanism for the Hyperexpression of Baculovirus Polyhedrin Gene
One of the amazing phenomena in the baculovirus life cycle is the hyperexpression of the very late gene, polyhedrin ( polh) , causing the production of the occlusion bodies where progeny virions are embedded. In this review, the mechanism responsible for polh hyperexpression from the previous studies was comprehensively summarized from three aspects, namely the structural characteristics of the polh promoter and transcriptional regulation, the structure and translational regulation of the polh mRNA, and especially the regulators that influence the expression of polh, hoping to help better understanding the regulatory molecular mechanism of hyperexpression of polh and provide theoretical guid-ance for improving the expression efficiency of foreign proteins by adopting the baculovirus expression vector system.
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