Clinical study on the treatment of anxiety insomnia caused by hyperactivety of fire due to yin deficiency with Hufu Tongbian Guasha combined with modified Huanglian Ejiao decoction
Objective To analyze the clinical effect of Hufu Tongbian Guasha combined with Huanglian Ejiao decoction in treating anxiety insomnia caused by hyperactivety of fire due to yin deficiency.Methods A total of 80 patients with anxiety insomnia caused by hyperactivety of fire due to yin deficiency admitted to the hospital from August 2020 to December 2022 were selected and divided into three groups according to random number table method,namely Guasha group(n=26,Hufu Tongbian Guasha treatment),traditional Chinese medicine(TCM)group(n=26,modified Huanglian Ejiao decoction treatment),and the combined treatment group(n=28,Hufu Tongbian Guasha combined with modified Huanglian Ejiao decoction treatment).The treatment effect,sleep quality[Pittsburgh Sleep Quality Index(PSQI)],sleep process[polysomnography(PSG)sleep process index],neurotransmitter status[norepinephrine(NE),dopamine(DA),5-hydroxytryptamine(5-HT)]and TCM syndrome score of three groups were compared.Results The total effective rate of the combined treatment group(92.86％)was significantly higher than that of Guasha group(65.38％)and TCM group(69.23％)(P＜0.05).Compared with before treatment,the total score of PSQI and the scores of all factors in three groups showed a downward trend after treatment,and the scores in the combined treatment group were lower than those in Guasha group and TCM group(P＜0.05).After treatment,the number of arousal,sleep latency,wakening time,rapid eye movement sleep and latency in the combined treatment group were significantly lower than those in Guasha group and TCM group,while the sleep efficiency in the combined treatment group was significantly higher than that in Guasha group and TCM group(P＜0.05).After treatment,the levels of NE and DA decreased significantly and 5-HT level increased significantly in three groups.Among them,the combined treatment group had the greatest degree of change in indicators(P＜0.05).The TCM syndrome scores of three groups were significantly decreased after treatment,and the combined treatment group showed the largest decrease in score(P＜0.05).Conclusion Hufu Tongbian Guasha combined with modified Huanglian Ejiao decoction has significant clinical effect on patients with anxiety insomnia caused by hyperactivity of fire due to yin deficiency,which can effectively improve sleep quality of the patients.This therapy is worth promoting.
Hufu Tongbian GuashaHuanglian Ejiao decoctionhyperactivity of fire due to yin deficiencyinsomniasleep qualityneurotransmitterpolysomnography
万方数据
维普
