Effect of Xiaoerfeike granules in the treatment of children with bronchopneumonia
Objective To expolre the effect of Xiaoerfeike granules combined with nebulized inhalation of terbutaline sulfate solution on myocardial enzyme and platelet parameters in children with bronchopneumonia.Methods 86 children with bronchopneumonia admitted to Nanjing Jiangbei Hospital from February 2020 to June 2022 were selected and divided into the control group(43 cases)and the experiment group(43 cases)according to random number table method.Both groups received routine treatment.On the basis of the treatment,the control group received nebulized inhalation of terbutaline sulfate solution for treatment,and the experiment group was treated with Xiaoerfeike granules on the basis of the treatment of the control group.Both groups received continuous treatment for 1 week.The clinical efficacy and symptom recovery after 1 week of treatment,and the levels of inflammation indicators and myocardial enzyme indicators,and platelet parameters changes before treatment and after 1 week of treatment between two groups were compared.Results After 1 week of treatment,the total effective rate in the experiment group(90.70％)was higher than that in the control group(74.42％)(P＜0.05).The time for relief of cough and phlegm,the disappearance of moist rales in the lungs,the recovery of body temperature,and the absorption of chest X-ray lesions in the experiment group was shorter than that in the control group(P＜0.05).After 1 week of treatment,the levels of serum interleukin 4(IL-4),IL-13,interferon-γ(IFN-γ),creatine kinase isozyme MB(CK-MB),lactate dehydrogenase(LDH)and creatine kinase(CK),and whole blood platelet count(PLT)and platelet distribution width(PDW)in both groups were lower than those before treatment,and the experiment group was lower than the control group(P＜0.05).After 1 week of treatment,compared with before treatment,the whole blood mean platelet volume(MPV)in two groups increased,and the experiment group was higher than the control group(P＜0.05).Conclusion The combination of Xiaoerfeike granules and nebulized inhalation of terbutaline sulfate solution can effectively regulate platelet parameters,reduce inflammation and myocardial damage in children with bronchopneumonia,and thereby promote symptom recovery and improve therapeutic effect.
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