Therapeutic effect of Nafamostat on hemodialysis patients with high risk of bleeding tendency
Objective To study the therapeutic effect of Nafamostat on hemodialysis patients with high risk of bleeding tendency.Methods A total of 112 patients with high risk of bleeding tendency during hemodialysis admitted to Harbin 242 Hospital from May 2021 to March 2023 were selected as the study objects and divided into the control group(56 cases)and the observation group(56 cases)according to random number table method.All patients received anticoagulation treatment during dialysis.The control group was treated with anticoagulation without heparin,and the observation group was treated with anticoagulation with Nafamostat.Both groups were observed till dialysis was completed.The dialysis status,electrolytes before and after dialysis,nutritional indexes,coagulation function,renal function and dialysis adequacy were compared between two groups.Results In the observation group,the use time of blood filter was longer than that in the control group,and the anticoagulant efficiency of the venous kettle was higher than that in the control group(P＜0.05).After dialysis,compared with before dialysis,the serum sodium ion levels in two groups increased,and the observation group was higher than the control group(P＜0.05);The levels of serum potassium ion,serum creatinine(Scr)and urea nitrogen(BUN)in two groups decreased,and the observation group was lower than the control group(P＜0.05).After dialysis,compared with before dialysis,the platelet levels in the control group decreased and were lower than those in the observation group(P＜0.05);The level of plasma D-dimer(D-D)in the control group increased and was higher than that in the observation group(P＜0.05);The partial thromboplastin time(APTT)and prothrombin time(PT)in the observation group were prolonged and longer than those in the control group(P＜0.05).After dialysis,the urea clearance rate(KT/V)in the observation group was higher than that in the control group(P＜0.05).Conclusion Compared with anticoagulation without heparin,the use of Nafamostat in hemodialysis patients with high-risk of bleeding tendency can effectively improve the dialysis condition of patients,regulate electrolyte level and coagulation function,improve dialysis adequacy of patients,and do not have a greater impact on nutritional status.It has a good application effect.
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维普
