Effect of temporary small caliber pancreatic duct stenting combined with Qingyi Tongfu decoction in the treatment of biliary acute recurrent pancreatitis
Objective To observe the clinical effect of temporary small caliber pancreatic duct stenting combined with Qingyi Tongfu decoction in the treatment of biliary acute recurrent pancreatitis(ARP).Methods 78 patients with biliary ARP were selected and divided into the control group and the observation group according to random number table method,with 39 cases in each group.The control group was treated with temporary small caliber pancreatic duct stenting,and the observation group was treated with temporary small caliber pancreatic duct stenting and Qingyi Tongfu decoction.The traditional Chinese medicine(TCM)symptom score,acute physiology and chronic health evaluation(APACHE Ⅱ),bedside index of severity acute pancreatitis(BISAP),serum amylase(AMS),the levels of liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphate(ALP)and total bilirubin(TBIL)],and the levels of inflammatory factors[procalcitonin(PCT)and interleukin-1β(IL-1β)]between two groups were compared.The mortality and recurrence rate of two groups were calculated after 1 year of follow-up.Results After treatment,the scores of main symptoms and secondary symptoms,and total scores in the observation group were lower than those in the control group(P<0.05).After treatment,APACHE Ⅱ and BISAP scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of AMS,ALT,AST,ALP and TBIL in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of PCT and IL-1β in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in mortality between two groups after 1 year of follow-up(P>0.05).The recurrence rate in the observation group was lower than that in the control group(P<0.05).Conclusion Temporary small caliber pancreatic duct stenting combined with Qingyi Tongfu decoction can alleviate the clinical symptoms of patients with biliary ARP,reduce the severity of the disease and pancreatic injury,improve AMS level and liver function indicators,regulate the levels of inflammatory factors,and reduce the recurrence rate in patients with biliary ARP.
acute pancreatitistraditional Chinese medicinecurative effectbiliary acute pancreatitis
万方数据
维普
