Value of platelet to lymphocyte ratio and D-dimer combined with CHA2DS-VASc score in predicting major adverse cardiovascular events during hospitalization after percutaneous coronary intervention in acute myocardial infarction
Objective To explore the value of platelet to lymphocyte ratio(PLR)and D-Dimer(D-D)combined with CHA2DS2-VASc score in predicting major adverse cardiovascular events(MACE)during hospitalization after percutaneous coronary intervention(PCI)in acute myocardial infarction.Methods 89 patients with acute myocardial infarction who underwent PCI in the 904th Hospital of Chinese People's Liberation Army Joint Logistic Support Force from January 2017 to June 2022 were selected.Preoperative PLR and D-D values of the patients were detected.And the CHA2DS2-VASc score was calculated.Follow-up was conducted until discharge.The patients were divided into the occurrence group and the non-occurrence group according to whether MACE occurred during hospitalization.The clinical data of two groups were compared,and the influencing factors of MACE during hospitalization after PCI in acute myocardial infarction were analyzed.The area under the receiver operating characteristic(ROC)curve(AUC)was used to evaluate the predictive value of preoperative PLR,D-D values,CHA2DS2-VASc scores and their combination in the occurrence of MACE during hospitalization after PCI in acute myocardial infarction.Results At the time of follow-up until discharge,21 cases of 89 patients with acute myocardial infarction after PCI developed MACE;And the MACE incidence rate was 23.60%,including 13 cases of heart failure,1 case of malignant arrhythmia,1 case of cardiogenic death,3 cases of revascularization of target vessels,and 3 cases of recurrent myocardial infarction;And the remaining 68 cases(76.40%)did not have MACE.The age,the proportion of patients with history of heart failure,the preoperative Gensini score of coronary artery disease,C-reactive protein(CRP)level,PLR,D-D value and CHA2DS2-VASc score in the occurrence group were higher than those in the non-occurrence group(P<0.05).Logistic multivariate regression analysis showed that increased age,increased preoperative PLR,increased D-D values,and increased CHA2DS2-VASc scores were the influencing factors for MACE during hospitalization after PCI in acute myocardial infarction(P<0.05).ROC curve results showed that AUC values of preoperative PLR,D-D values,CHA2DS2-VAsc scores and their combination to predict MACE during hospitalization after PCI in acute myocardial infarction were 0.708,0.660,0.658,and 0.805 respectively(P<0.05).The combined AUC values of the above three indicators were higher than the AUC values detected by a single indicator(P<0.05).Conclusion PLR,D-D values and CHA2DS2-VASc scores have important value in predicting whether MACE occurs during hospitalization after PCI in acute myocardial infarction,and the combination of the three indicators has higher predictive value.
platelet to lymphocyte ratioD-dimerCHA2DS2-VASc scoreacute myocardial infarctionpercutaneous coronary interventionmajor adverse cardiovascular eventspredictive value
万方数据
维普
