Analysis of diagnostic efficacy of procalcitonin,C-reactive protein,interleukin-6 and serum amyloid A in bloodstream infections in patients with malignant tumors
Objective To explore the diagnostic efficacy of four serological infection indexes,namely procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6),and serum amyloid A(SAA)in bloodstream infections in patients with malignant tumors.Methods A total of 120 malignant tumor patients with clinically confirmed bloodstream infection with positive blood cultures were selected as the observation group,and 100 malignant tumor patients with negative blood cultures in the same period were selected as the control group.Serum PCT,CRP,IL-6,and SAA levels in both groups were recorded and compared.Receiver operator characteristic curves(ROC curve)were plotted to analyze the diagnostic efficacy of four infection indexes mentioned above,and the sensitivity,specificity and Youden index of single detection and multi-item combined detection levels were calculated.Results The serum concentrations of PCT,CRP,IL-6 and SAA in the observation group were significantly higher than those in the control group,and there was statistically significant difference(P＜0.01).The ROC curve showed that the area under the curve of PCT was relatively large(0.935),and the optimal cut-off value was 0.594ng·mL-1,the specificity and sensitivity at this time were 96％and 83％,respectively,which had certain diagnostic value,but did not have sufficient sensitivity.The combined detection of PCT,CRP,SAA,and IL6 had high diagnostic value for bloodstream infection in patients with malignant tumors,because the area under the curve was the largest(0.981),the sensitivity reached 92％,and the diagnostic efficacy was the best.Conclusion Patients with malignant tumors are more likely to develop bloodstream infections,because they are generally older and have underlying diseases,and the body's ability to resist pathogen infection decreases.The combined detection of PCT,CRP,SAA and IL6 has high application value in the early diagnosis of bloodstream infection,which can improve the accuracy of clinical diagnosis of this disease to a certain extent,improve the prognosis of patients,and reduce the mortality.
万方数据
维普
