目的 探讨血栓通注射液对急性脑梗死患者脑血流动力学及血清学指标的影响.方法 将160例2022年1月-2022年12月伊犁州奎屯医院神经内科收治的急性脑梗死患者随机纳入对照组和试验组,各80例.经脱落或剔除后纳入120例患者进行研究,其中对照组50例、试验组70例.对照组给予西医常规治疗,试验组在对照组基础上给予血栓通注射液进行治疗,2组均治疗2周.比较2组治疗2周后的临床疗效;治疗前和治疗2周后的神经功能、自理能力、脑血流动力学、血清学指标及治疗期间的不良反应.结果 试验组治疗2周后的总有效率为94.29％,高于对照组的80.00％(P＜0.05);治疗2周后,2组美国国立卫生院神经功能缺损评分(National Institutes of Health Stroke Scale,NIHSS)、改良 Rankin 量表(Modified Rankin Scale,mRS)评分、左侧颈总动脉动态阻力(dynamic resistance,DR)、外周阻力(peripheral resistance,Rv)及血清钙结合蛋白β(calcium-binding protein β,S-100β)、神经元特异性烯醇化酶(neuron specific enolase,NSE)、单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)、同型半胱氨酸(homocysteine,Hcy)水平与治疗前比较降低,且试验组低于对照组(P＜0.05);2组日常生活活动能力(activities of daily living,ADL)评分及左侧颈总动脉平均血流速率(Vm)、平均血流量(Qm)与治疗前比较升高,且试验组高于对照组(P＜0.05).结论 血栓通注射液可明显改善急性脑梗死患者脑血流动力学,调节血清学指标水平变化,进而有助于促进患者神经功能、炎症反应和自理能力的改善,提高临床疗效,且并未明显增加患者的不良反应.
Effects of Xueshuantong injection on cerebral hemodynamics and serological indexes in patients with acute cerebral infarction
Objective To explore the effects of Xueshuantong injection on cerebral hemodynamics and serological indexes in patients with acute cerebral infarction.Methods 160 patients with acute cerebral infarction admitted to the Department of Neurology of Kuitun Hospital of IIi Kazakh Autonomous Prefecture from January 2022 to December 2022 were randomly divided into the control group(80 cases)and the experiment group(80 cases).After dropout or exclusion,120 patients were included in the study,including 50 cases in the control group and 70 cases in the experiment group.The control group was given conventional Western medicine,and the experiment group was given Xueshuantong injection on the basis of the treatment of the control group.Both groups were treated for 2 weeks.The clinical efficacy after 2 weeks of treatment,the neurological function,self-care ability,cerebral hemodynamics,serological indexes before treatment and after 2 weeks of treatment,and adverse reactions during treatment were compared between two groups.Results The total effective rate of the experiment group after 2 weeks of treatment was 94.29％,which was higher than that of the control group(80.00％)(P＜0.05).After 2 weeks of treatment,the scores of National Institutes of Health Stroke Scale(NIHSS),Modified Rankin Scale(mRS),left common carotid artery dynamic resistance(DR),peripheral resistance(Rv),and serum levels of calcium-binding protein β(S-100β),neuron specific enolase(NSE),monocyte chemoattractant protein-1(MCP-1)and homocysteine(Hcy)in two groups decreased compared with before treatment,and the experiment group was lower than the control group(P＜0.05);the score of activities of daily living(ADL),left common carotid artery velocity mean(Vm)and Qmean(Qm)in two groups increased compared with before treatment,and the experiment group was higher than the control group(P＜0.05).Conclusion Xueshuantong injection can significantly improve cerebral hemodynamics in patients with acute cerebral infarction,regulate changes in serum indicators levels,and thereby help promote the improvement of patients'neurological function,inflammatory reaction and self-care ability,improve clinical efficacy,and do not significantly increase adverse reactions in patients.
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