Effect of Remimazolam on the quality of recovery from anesthesia,inflammatory stress and postoperative delirium in elderly patients after hip replacement
Objective To explore the effect of Remimazolam on the quality of recovery from anesthesia,inflammatory stress and postoperative delirium in elderly patients after hip replacement.Methods 94 elderly patients with hip replacement in Qinhuangdao Hospial of Peking University Third Hospital from November 2021 to March 2023 were divided into group A and group B according to random number table method,with 47 patients in each group.Group A was given Midazolam,Sufentanil and Rocuronium bromide for anesthesia induction,while the group B was given Remimazolam,Sufentanil and Rocuronium bromide for anesthesia induction.All patients were observed till they were discharged from hospital.The scores of Riker Sedation-Agitation Scale(RSAS)of recovery period,vital signs and cognitive function at different time points,inflammatory stress before operaion and 72 hours after operation,and incedence of complications during postoperative hospitalization were compared between two groups.Results Compared with 42.55％of patients with recovery RSAS score≥5 in group A,10.64％in group B was relatively lower(P＜0.05).Compared with T0,the heart rate(HR)and mean arterial pressure(MAP)of patients in T1～T3 of both groups all decreased at first and then increased,and group B was higher than group A(P＜0.05).At 72 hours after operation,the levels of serum adrenocorticotropic hormone(ACTH),nitric oxide(NO),C-reactive protein(CRP)and interleukin-1β(IL-1β)in two groups were higher than those before operation,and group B was lower than group A(P＜0.05).Compared with T4,the cognitive function scores of T5,T3 and T6 in 2 groups all decreased first and then increased,and group B was higher than group A(P＜0.05).During postoperative hospitalization,compared with group A,the proportion of patients with delirium and hypoxemia in group B was relatively lower(P＜0.05).Conclusion Remimazolam can effectively improve the recovery quality of elderly patients after hip replacement,relieve the inflammatory stress reaction of patients,stabilize the vital signs of patients,improve the cognitive function of patients,reduce the incidence of postoperative delirium and hypoxemia,and has good safety.
hip replacementold ageRemimazolamquality of recovery from anesthesiainflammationstressdelirium
万方数据
维普
