Neuroprotective effects and clinical progress of salvianolic acid B in animal models of Parkinson's disease
As a progressive neurodegenerative disease,Parkinson's disease has a high incidence in the elderly population.The main pathological mechanisms are dopamine neuron loss,neurofibrillary tangles formation,oxidative stress and mitochondrial dysfunction,inflammatory reaction and abnormal protein metabolism.Salvianolic acid B,as an active ingredient extracted from Radix Salviae Miltiorrhizae,has neuroprotective effects on Parkinson's disease through antioxidation,improving mitochondrial function,regulating neuroinflammation,inhibiting apoptosis,promoting neuron differentiation and proliferation,and affecting intestinal flora.Salvianolic acid B,as an auxiliary drug,combined with conventional drugs,has the effect of enhancing curative efficacy and reducing side effects,which provides methods and basis for early diagnosis and treatment of Parkinson's disease in clinical practice.
Parkinson's diseasesalvianolic acid Bneuroprotectionantioxidationneuroinflammationinhibiting apoptosismitochondrial function
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