摘要
通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出柴胡:功效主要为疏散退热,疏肝解郁,升举阳气.症靶为发热、焦虑抑郁、口苦、胸胁不适、闭经、月经不调等.现代药理研究发现,柴胡及其有效成分具有抗炎、抗病毒、抗菌、抗抑郁、解热、保肝、抗癌、免疫调节、抗癫痫等作用.柴胡其性升散,古人有"柴胡劫肝阴"之说,阴虚阳亢、肝风内动、阴虚火旺及气机上逆者忌用或慎用.药典规定剂量3～10g,现代临床使用剂量为3～60g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索柴胡用量与症靶的量效关系构建.
Abstract
Through the investigation of ancient books and the sorting of the modem research achievements of traditional Chinese medicine,combined with the understanding and application experience of famous experts and scholars in the fields of traditional Chinese medicine clinical medicine and science of Chinese materia medica,it is concluded that Chinese thorowax root mainly has the effects of removing fever,dispersing stagnated liver qi for relieving qi stagnation,and raising yang.The symptom targets are fever,anxiety and depression,bitter tast in mouth,discomfort in chest and hypochondrium,amenorrhea,and menstrual disorders.Modern pharmacology studies have found that Chinese thorowax root and its active ingredients have the effects of anti-inflammatory,antivirulence,antisepsis,antidepressant,antifebrile,liver-protection,anticancer,immunoregulation,and anti epilepsy.The medicinal properties of Chinese thorowax root are ascending and dispersive.There was the saying in ancient times that"Chinese thorowax root harms liver yin".People with hyperactivity of yang due to yin deficiency,liver wind stirring up internally,hyperactivity of fire due to yin deficiency,and adverse qi movement should avoid or use with caution.Pharmacopoeia prescribes the dosage of 3-10g,and the modern clinical dosage is 3-60g.When taken orally,it should be used dialectically according to different diseases or different stages of the same disease,and the construction of dose-effect relationship between the dosage of Chinese thorowax root and the symptom target should be explored actively.
基金项目
中国科学院学部咨询评议项目(2021-ZW10-A-017)
国家自然科学基金面上项目(81973837)
维普
万方数据