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重构本草——肉苁蓉

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通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内专家学者的认识及应用经验,归纳出肉苁蓉:主要功效为补肾阳,益精血,润肠通便.症靶为便秘、阳痿.现代药理研究发现,肉苁蓉及其有效成分具有调节肠道菌群、促进排便、改善生殖功能、促进雄激素分泌、抗氧化、抗衰老、抗骨质疏松、降血糖血脂、抗炎等作用.现有实验数据显示,肉苁蓉是无毒或低毒性物质,阴虚火旺及大便溏泄者不宜服用,肠胃实热、热结便秘者忌用.临床使用剂量为6~60 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索肉苁蓉用量与症靶的量效关系构建.
Reconstruction of Chinese materia medica-desertliving cistanche
Through the investigation of ancient books and the sorting of modern research achievements of traditional Chinese medicine,combined with the understanding and application experience of famous experts and scholars in the fields of traditional Chinese medicine clinical medicine and science of Chinese materia medica,it is concluded that desertliving cistanche mainly has the effects of invigorating kidney yang,tonifying essence and blood,and smoothing intestine and relieving constipation.The symptom targets are constipation and impotence.Modern pharmacology studies have found that desertliving cistanche and its active components have the effects of regulating intestinal microbiota,promoting defecation,improving reproductive function,promoting androgen secretion,anti-oxidation,anti-aging,anti-osteoporosis,lowering blood sugar and lipids levels,anti-inflammatory and so on.Existing experimental data show that desertliving cistanche is non-toxic or low toxic substance.People with hyperactivity of fire due to yin deficiency and loose stools should not take it.And people with excessive heat in the gastrointestinal tract or heat accumulation of large intestine and constipation should avoid using it.The clinical dosage is 6-60g.When taken orally,it should be used according to syndrome differentiation of different diseases or different stages of the same disease,and the construction of dose-effect relationship between the dosage of desertliving cistanche and the symptom target should be explored actively.

desertliving cistanchesymptom targetreconstruction of Chinese materia medicaclinical verification

马凯乐、赵旌屹、张艳娇、田传玺、张伟、李敏

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中国中医科学院广安门医院,北京 100053

甘肃中医药大学基础医学院,兰州 730000

肉苁蓉 症靶 重构本草 临床回归

中国中医科学院科技创新工程项目

CI2021A01606

2024

长春中医药大学学报
长春中医药大学

长春中医药大学学报

CSTPCD
影响因子:0.916
ISSN:1007-4813
年,卷(期):2024.40(4)
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