Clinical study on treatment of diarrhea of diabetes mellitus type 2 caused by metformin with acupoint application of traditional Chinese medicine
Objective To explore the clinical therapeutic effect of acupoint application of traditional Chinese medicine on diarrhea of diabetes mellitus type 2 caused by metformin.Methods 126 patients of diabetes mellitus type 2 with diarrhea caused by metformin were randomly divided into the control group and the observation group,with 63 cases in each group.The control group was treated with bifidobacterium triple viable capsules on the basis of the treatment of Western medicine such as metformin,while the observation group was treated with acupoint application of traditional Chinese medicine on the basis of the treatment of the control group.Traditional Chinese medicine syndrome scores,changes in stool characteristics,enteric flora count,blood glucose levels,clinical efficacy,and treatment safety between two groups after 2 weeks of treatment were observed.Results After 2 weeks of treatment,two groups showed the decrease in loose stools,increased frequency of defecation,loss of appetite,postprandial abdominal distension,integral of extremities and cold syndrome,score of stool form,number of urgent defecation days in 10 days,maximum daily defecation frequency,and number of enterobacteriaceae and enterococcus(P＜0.05),and the observation group was lower than the control group(P＜0.05).After 2 weeks of treatment,the number of lactobacilli and bifidobacteria in both groups increased(P＜0.05),and the observation group was more than the control group(P＜0.05).After 2 weeks of treatment,fasting blood glucose and 2-hour postprandial blood glucose decreased in both groups(P＜0.05),but there was no statistically significant difference between the groups(P＞0.05).The total effective rate of the observation group(92.1％,58/63)was significantly higher than that of the control group(71.4％,45/63)(P＜0.05).No significant adverse reactions were observed during the treatment of both groups.Conclusion Acupoint application of traditional Chinese medicine can effectively relieve diarrhea symptoms of diabetes mellitus type 2 patients caused by metformin,regulate enteric flora derangement,improve gastrointestinal function of patients,and maintain good sugar control effect.
metformindiabetes mellitus type 2diarrheaacupoint application of traditional Chinese medicineenteric flora derangementblood glucose level
万方数据
维普
