Study on the diagnosis of early childhood Mycoplasma pneumoniae pneumonia with serum C-reactive protein and serum amyloid protein A
Objective To explore the clinical value of serum C-reactive protein(CRP)and serum amyloid A(SAA)levels in the diagnosis of Mycoplasma pneumoniae pneumonia in children.Methods Sixty children with Mycoplasma pneumoniae pneumonia admitted for treatment from January 2021 to December 2022 were selected as the observation group,and anothor 60 healthy children who underwent physical examinations during the same period were selected as the control group.Fasting venous blood was collected from two groups,and the CRP and SAA levels were measured.CRP and SAA levels of two groups were compared.And the diagnostic efficacy of serum CRP level detection alone,serum SAA level detection alone,and combined detection of two indicator levels for pediatric Mycoplasma pneumoniae pneumonia was compared.Results The levels of serum CRP and SAA in the observation group were higher than those in the control group(P＜0.05).Using the results of pathogen detection as the gold standard,serum CRP level detection showed 50 positive patients and 70 negative patients with Mycoplasma pneumoniae pneumonia in children;The serum SAA level detection showed that there were 55 positive patients and 65 negative patients with Mycoplasma pneumoniae pneumonia in children;The combined detection of serum CRP level and SAA level showed 57 positive patients and 63 negative patients with Mycoplasma pneumoniae pneumonia in children.The sensitivity of serum CRP level alone,SAA level alone and combined detection level of both for diagnosing Mycoplasma pneumoniae pneumonia in children was 75.00％,86.67％and 91.66％,respectively.The specificity was 91.67％,95.00％,and 96.67％,respectively.The Kappa values were 0.833,0.908,and 0.942,respectively.The sensitivity and specificity of the combined detection level of serum CRP and SAA in diagnosing Mycoplasma pneumoniae pneumonia in children were higher than those of the detection level of serum CRP alone and the detection level of serum SAA alone.The ROC curve results showed that the AUC value of serum CRP alone for diagnosing Mycoplasma pneumoniae pneumonia in children was 0.835(95％CI:0.718-0.880),with a cutoff value of 11.55mg·L-1;The AUC value of serum SAA alone for diagnosing Mycoplasma pneumoniae pneumonia in children was 0.895(95％CI:0.832-0.958),with a cutoff value of 30.45 mg·L-1;The AUC value of combined detection of both was 0.965(95％CI:0.933-0.998)(P＜0.05).Conclusion CRP and SAA levels have high diagnostic value for Mycoplasma pneumoniae pneumonia in children,and the combined detection level of these two indicators has the better diagnostic efficiency,with high sensitivity and specificity,which can provide reference for clinical diagnosis of pediatric Mycoplasma pneumoniae pneumonia.
serum C-reactive proteinserum amyloid protein AMycoplasma pneumoniae pneumoniainfection markerdiagnostic value
万方数据
维普
