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葛根治疫浅析

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葛根治疫,溯源弥久.性平辛甘,善走表以升阳解肌、通络以生津解毒,多用于诊治温热疫.如徐氏葛根汤,合膏、芩清解少阳阳明邪热,合麻黄透邪外达、截断病势,以治天行热疫之痘疹欲出者;陈氏葛根汤,合荆、桔、翘等轻清扬上之品,以治疫毒蕴结肺胃之疫痧证;《局方》升麻葛根汤,合升麻火郁发之,以治麻疹初起不透者;陈氏升麻葛根汤,合柴、芩、栀疏利清解三焦,以治气滞血热之丹毒证.现代药理,则多从免疫应答、炎症介质角度阐述其解热、抗病毒等治疫机制.通过上述对葛根药性、方剂配伍、药理研究多个角度的系统梳理,探讨其治疫理论及机制,为临床应用及新药开发提供参考依据.
Analysis of kudz uvne root in the treatment of epidemic diseases
Tracing back to its source,kudze uvne root has been used for a long time to treat the epidemic disease. Kudze uvne root has the mild nature,and its taste is both spicy and sweet. It is good at treating relatively superficial diseases for promoting spleen yang and resolving the flesh,and removing obstruction in collaterals for promoting fluid production and detoxication,so it is often used for the diagnosis and treatment of syndrome of warm-heat and pestilent toxin. For example,Xu's gegen decoction combined with gao and Scutellaria baicalensis can dissipate Shaoyang and Yangming evil fever,while Xu's gegen decoction combined with ephedra herb can remove pathogeneses and cut off the disease progression,in order to treat the patients who want to develop Variola due to acute febrile infectious disease;Chen's gegen decoction combined with medicines with a light and uplifting nature such as Schizonepeta,Platycodon grandifl orum,forsythia and so on,is used to treat scarlet fever,where the epidemic toxins accumulate in the lungs and stomach;In "Prescriptions of Pharmacy Bureau",shengma gegen decoction combined with largetrifoliolious bugbane rhizome can treat fire stagnation,in order to treat the early stage of measles without adequate eruption;Chen's shengma gegen decoction combined with radix bupleuri,Scutellaria baicalensis and Gardenia can unblock and clear Sanjiao meridian,in order to treat erysipelas of stagnation of qi and blood stasis. In modern pharmacology,the mechanism of antipyretic and antiviral treatment is mainly elaborated from the perspectives of immune response and inflammatory mediators. Through the systematic review of the medicinal properties,prescription compatibility and pharmacological research of kudze uvne root,this article explores the theory and mechanism in treating epidemic diseases,in order to provide reference for clinical application and new drug development.

kudze uvne rootgegen decoctionshengma gegen decoctionepidemic disease

张文风、罗绍东

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长春中医药大学,长春 130117

葛根 葛根汤 升麻葛根汤 疫病

国家社会科学基金应急管理体系建设研究专项吉林省卫生健康委项目吉林省中医药局项目张文风名老中医专家传承工作室项目

20VYJ0702021GW006

2024

长春中医药大学学报
长春中医药大学

长春中医药大学学报

CSTPCD
影响因子:0.916
ISSN:1007-4813
年,卷(期):2024.40(5)
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