首页|重构本草——酸枣仁

重构本草——酸枣仁

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通过研究古籍文献、整理中医药现代研究成果,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出酸枣仁:功效主要为养血敛阴.症靶为失眠、心慌心悸.现代药理研究发现酸枣仁及其有效成分具有镇静催眠、抗焦虑、调节免疫、抗氧化、增强学习记忆,以及抗肿瘤、保肝等作用.酸枣仁及其提取物口服时毒性很小,但胃肠道外给药时毒性显著增加,口服给药保证用药安全.同时酸枣仁敛阴润燥性强,故有实邪、郁火或滑泄症者应慎用,避免闭门留寇或加重泄泻.临床使用剂量为15~30 g,内服时应结合疾病、症状选择药物最佳剂量与配伍.
Reconstruction of Chinese materia medica-spine date seed
Through the investigation of ancient books and the sorting of the modern research achievements of traditional Chinese medicine,combined with the understanding and application experience of well-known experts and scholars in desciplinary fields such as traditional Chinese medicine clinical medicine and science of Chinese materia medica,it is concluded that spine date seed mainly has the effect of nourishing blood and retaining yin with astringent. The symptom targets are insomnia,and palpitations. Modern pharmacological studies have found that spine date seed and its active ingredients have the effects of tranquilization and hypnogenesis,anti-anxiety,immunomodulation,antioxidation,enhancement of learning and memory,as well as anti-tumor and liver protection. Spine date seed and its extracts have minimal toxicy when taken orally,but the toxicy significantly increases during parenteral administration. Oral administration ensures medication safety. At the same time,spine date seed has strong ability to retain yin with astringent and moisturize dryness-syndrome. Therefore,people with excessive pathogen,stagnated fire and lingering diarrhea should use them with caution to avoid improper use of nourinshing drugs or methods leading to worsening or difficult to cure conditons. The clinical dosage is 15-30g,and the optimal dosage and compatibility of the medication should be selected based on the disease and symptons during oral administration.

spine date seedsymptom targetbiochemical indicator targetreconstruction of Chinese materia medicaclinical verification

徐鑫梓、吴辉、黄博文、杜雅明、沈梦菲、张伟、陈国华

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武汉市中西医结合医院,武汉 430022

北京中医药大学,北京 100029

中国中医科学院广安门医院代谢病研究所,北京 100053

甘肃中医药大学基础医学院,兰州 730000

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酸枣仁 症靶 标靶 重构本草 临床回归

中国科学院学部咨询评议项目国家自然科学基金面上项目中国中医科学院科技创新工程创新团队项目

2021-ZW10-A-01781973837CI2021B008

2024

长春中医药大学学报
长春中医药大学

长春中医药大学学报

CSTPCD
影响因子:0.916
ISSN:1007-4813
年,卷(期):2024.40(5)
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