Effects of diabetes mellitus on sexual function,histomorphology and α-smooth muscle actin expression in cavernous body of penis in rats
Objective To observe the sexual function of diabetes model rats and explore the possible mechanism of secondary sexual dysfunction caused by hyperglycemia. Methods The experimental rats were randomly divided into the blank group (n=5) and the diabetes group (n=15). After the diabetes animal model was successfully constructed,the sexual function of two groups was evaluated. The histological characteristics of testis in two groups were observed.The expression of α-smooth muscle actin (α-SMA) in penile tissue of two groups was measured. Results The levels of serum sex hormones were significantly decreased (P＜0.01). Histomorphological observation showed that in the diabetes group the interstitial tissue of testis was disordered;Compared with the blank group,the number of smooth muscle cells in the penis tissue was reduced,and the degree of fibrosis was aggravated. The expression of α-SMA positive cells in the diabetes group was significantly decreased (P＜0.01). Conclusion The decreased levels of sex hormones,the decreased number of smooth muscle cells in cavernous body of penis,the decreased expression of α-SMA in cavernous body of penis,the disordered structure of interstitial tissue of testis,the morphological changes of smooth muscle cells and the aggravation of fibrosis in the diabetes rats are important phenotypic features of this disease. Exploring the diagnosis and treatment of this disease with this phenotypic features will be of great significance.
万方数据
维普
