Effect of liver and spleen-regulating and blood stasis and phlegm-dispelling on perioperative period of pars plana vitrectomy in proliferative diabetic retinopathy
Objective To explore the effect of "liver and spleen-regulating and blood stasis and phlegm-dispelling" on the perioperative period of patients with proliferative diabetic retinopathy (PDR) undergoing pars plana vitrectomy (PPV). Methods 63 patients with PDR admitted to Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine from June 2021 to June 2023 were selected and divided into the conventional group (n=31) and the simultaneous regulating group (n=32) according to the simple randomization method. The conventional group received rutine perioperative treatment (3-5 days before surgery to 7 days after surgery),while the simultaneous regulating group received "liver and spleen-regulating and blood stasis and phlegm-dispelling" on the basis of the treatment of the conventional group. The clinical indicators,complications (high intraocular pressure,vitreous hemorrhage,decreased visual acuity),intraocular pressure and inflammatory response grading (anterior chamber flare,anterior chamber inflammatory cells,fibrin exudation),and levels of inflammatory factors[anterior chamber fluid interleukin-6 (IL-6),serum C-reactive protein (CRP)]before and after intervention were compared between two groups. Results The surgical time and hospital stay in the simultaneous regulating group were shorter than those in the conventional group (P＜0.05). There was no statistically significance diference in the total incidence rate of complications between two groups (P＞0.05). At 1 day and 3 days after surgery,the intraocular pressure in two groups decreased with time (P＜0.05),and at 1 day after surgery,the simultaneous regulating group was lower than the conventional group (P＜0.05). At 1 day and 1 week after surgery,the anterior chamber flare,anterior chamber inflammatory cells and fibrin exudation ratings in both groups were obviously relieved with time (P＜0.05),and at 1 day after surgery,the anterior chamber flare rating in the simultaneous regulating group was significantly lower than that in the conventional group (P＜0.05). At 1 day and 1 week after surgery,the levels of anterior chamber fluid IL-6 and serum CRP in both groups were reduced with time (P＜0.05),and the simultaneous regulating group was lower than the conventional group (P＜0.05). Conclusion The application of "liver and spleen-regulating and blood stasis and phlegm-dispelling" can reduce perioperative complications,effectively control the inflammatory response,and shorten the surgical time and hospital stay in patients with PDR undergoing PPV. This therapy has clinical application value.
proliferative diabetic retinopathypars plana vitrectomyliver and spleen-regulating and blood stasis and phlegm-dispelling
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