Clinical study of indomethacin combined with ceftazidime in the prevention of postoperative pancreatitis in patients with choledocholithiasis after endoscopic retrograde cholangiopancreatography
Objective To explore the preventive effect of indomethacin combined with ceftazidime on postoperative pancreatitis in patients with choledocholithiasis after endoscopic retrograde cholangiopancreatography (ERCP). Methods A total of 128 patients with choledocholithiasis who developed pancreatitis after ERCP and were admitted to Fuyang People's Hospital in Anhui Province from March 2020 to December 2021 were selected and randomly divided into the study group and the control group according to random number table method,with 64 cases in each group. The control group received ceftazidime treatment;The study group received indomethacin treatment on the basis of the treatment of the control group. The operation time,the number of gastric peristalsis during the operation,the improvement time of clinical symptoms,preoperative and postoperative serum amylase (AMS) and white blood cells (WBC) levels,the recovery of gastrointestinal function,and postoperative pancreatitis were compared between two groups. Results There were statistically significant differences in the operation time and the number of gastric peristalsis during the operation between two groups (P＜0.05). After treatment,the recovery time of serum AMS levels and hospitalization time of the study group were shorter than those of the control group (P＜0.05). After surgery,the levels of AMS and WBC in both groups decreased,and the study group was lower than the control group (P＜0.05). The first postoperative feeding time,the first postoperative anal exhaust time and the first postoperative defecation time of the study group were shorter than those of the control group (P＜0.05). The total incidence of postoperative pancreatitis in the study group was lower than that in the control group (P＜0.05). Conclusion Indomethacin combined with ceftazidime can improve perioperative indexes in patients with choledocholithiasis,reduce AMS and WBC levels,promote gastrointestinal function recovery,and reduce the incidence of postoperative pancreatitis. This therapy is safe.
万方数据
维普
