Effect of low-dose naloxone combined with general anesthesia on the quality of recovery and postoperative pain in patients undergoing radical operation of cervical cancer
Objective To explore the effect of low-dose naloxone combined with general anesthesia on the quality of recovery and postoperative pain in patients undergoing radical operation of cervical cancer. Methods A total of 280 patients with cervical cancer admitted to Lianyungang First People's Hospital from September 2021 to December 2022 were selected and divided into the observation group and the control group according to random number table method,with 140 cases in each group. Both groups underwent radical operation of cervical cancer. Tracheal intubation and general anesthesia,anesthetic induction,anesthesia maintenance and postoperative analgesic drugs in both groups were the same. 5 ml of normal saline was injected intravenously 5 minutes before anesthesia induction in the control group,and 50 ng·kg-1 of naloxone (diluted to 100 ml with normal saline) was injected intravenously 5 minutes before anesthesia induction in the observation group.The quality of recovery,dosage of sufentanil at different times after surgery,visual analogue scale (VAS) scores,mechanical pain threshold around the incision,and incidence of adverse reactions within 24 hours after surgery between two groups were compared. Results Respiratory recovery time,eye opening time,extubation time,orientation recovery time and time to return to the ward in the observation group were shorter than those in the control group (P＜0.05). The dosage of sufentanil used at different times after surgery in the observation group was lower than that in the control group (P＜0.05);The resting VAS score and active VAS score of the observation group at different times after surgery were lower than those of the control group (P＜0.05);The mechanical pain threshold values around the incision at 3,6,12 and 24 hours after surgery in the observation group were higher than those in the control group (P＜0.05);The incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05). Conclusion The application of low-dose naloxone in patients undergoing radical operation of cervical cancer under general anesthesia can improve postoperative recovery quality,prevent postoperative pain sensitization,alleviate postoperative pain,reduce postoperative sufentanil dosage,and reduce the incidence of adverse reactions within 24 hours after surgery.
small dosenaloxonegeneral anesthesiaradical operation of cervical cancerpostoperative recovery qualitypain
万方数据
维普
