Observation on the therapeutic effect of method of benefiting qi and removing obstruction in collaterals and detoxication combined with bevacizumab in the treatment of relapse and metastasis rectal cancer
Objective To observe the clinical efficacy of method of benefiting qi and removing obstruction in collaterals and detoxication combined with bevacizumab in the treatment of relapse and metastasis rectal cancer.Methods 80 patients with relapse and metastasis rectal cancer admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2019 to June 2022 were selected and divided into the targeted group and the traditional Chinese medicine(TCM)group according to random number table method,with 40 cases in each group.Both groups were treated with FOLFIRI for chemotherapy.The targeted group was treated with bevacizumab for targeted therapy,and the TCM group was treated with benefiting qi and removing obstruction in collaterals and detoxication prescription based on the treatment of the targeted group.The objective effective rate,clinical benefit rate,and toxic reaction degree of two groups were statistically analyzed.TCM symptom scores,and the levels of vascular endothelial cell growth factor(VEGF),matrix metalloproteinase-2(MMP-2)and insulin-like growth factor 1(IGF-1)were compared between two groups.Results There was no statistically significant difference in the objetive effective rates between the TCM group(55.00％,22/40)and the targeted group(35.00％,14/40)(P＞0.05).The clinical benefit rate in the TCM group(92.50％,37/40)was higher than that in the targeted group(75.00％,30/40)(P＜0.05).Before treatment,there was no statistically significant difference in TCM symptom scores between two groups(P＞0.05).Compared with before treatment,abdominal distension,abdominal pain,poor appetite,fatigue,dry feces,loose stool,and hemafecia scores and total score of two groups were decreased after treatment,and the TCM group was lower than the targeted group(P＜0.05).Before treatment,there was no statistically significant difference in the levels of VEGF,MMP-2 and IGF-1 between two groups(P＞0.05).Compared with before treatment,the levels of VEGF,MMP-2 and IGF-1 decreased after treatment,and the TCM group was lower than the targeted group(P＜0.05).The degree of myelosuppression,delayed diarrhea,and toxic reaction in the TCM group was lower than that in the targeted group.There was no statistically significant difference in the degree of gastrointestinal reactions,peripheral neurotoxicity,liver and kidney damage,and toxic reaction between two groups(P＞0.05).Conclusion Method of benefiting qi and removing obstruction in collaterals and detoxication combined with bevacizumab in the treatment of relapse and metastasis rectal cancer can reduce the expression levels of VEGF,MMP-2 and IGF-1,which plays the role in enhancing efficacy and reducing toxicity.
benefiting qi and removing obstruction in collaterals and detoxication prescriptionbevacizumabrectal cancerrelapsemetastasis
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