Value of ultrasound parameters combined with serum biomarkers in differentiation of benign and malignant ovarian tumors
Objective To explore the value of ultrasound parameters combined with serum human epididymal protein 4(HE4),human kallikrein 10(hk10),and DJ-1 in the differentiation of benign and malignant ovarian tumors.Methods 100 patients with ovarian tumors admitted to Fuyang Cancer Hospital from January 2020 to January 2023 were selected and divided into the benign ovarian tumor group(n=80)and the malignant ovarian tumor group(n=20)according to pathological results.All patients underwent preoperative ultrasound examination and the detection of serum HE4,hkl0 and DJ-1 levels,and the differences in various indicators between two groups were compared.The diagnostic effect of ultrasound parameters,HE4,hk10,and DJ-1 on ovarian malignant tumors was analyzed through ROC.Results The levels of RI,PI,S/D,HE4,hk10 and DJ-1 in the benign ovarian tumor group were lower than those in the malignant ovarian tumor group(P＜0.05);The results of receiver operator characteristic curve(ROC curve)showed that the sensitivity of RI,PI,S/D,HE4,hkl0 and DJ-1 in diagnosing malignant ovarian tumor was 0.698,0.721,0.744,0.721,0.814,0.814 respectively,the sensitivity of combined diagnosis was 0.953;The specificity was 0.719,0.789,0.491,0.737,0.684,0.877 respectively,and the specificity of combined diagnosis was 0.912;The RI,PI,S/D,HE4,hk10,and DJ-1 levels in patients with stage Ⅰ-Ⅱ malignant ovarian tumor were lower than those in patients with stage Ⅲ-Ⅳ malignant ovarian tumor(P＜0.05).Conclusion Ultrasound parameters,HE4,hk10,and DJ-1 can all be used as indicators to differentiate between benign and malignant ovarian tumors.
ultrasonic parametershuman epididymal protein 4human kallikrein 10DJ-1 proteinovarian tumor
万方数据
维普
