Effect of intraoperative nebulization of budesonide on respiratory function in elderly patients
Objective To explore the effect of nebulized budesonide inhalation on respiratory function in elderly patients during laparoscopic rectal cancer surgery.Methods 112 patients who underwent laparoscopic rectal cancer surgery were selected and divided into the observation group and the control group according to random number table method,with 56 cases in each group.Before surgery,both groups inhaled ipratropium bromide through nebulization.During surgery,the observation group additionally inhaled nebulized budesonide.Arterial blood gas indicators before anesthesia(T1)and at 10 minutes after anesthesia recovery(T2)between two groups were compared,and serum levels of interleukin-6(IL-6),eosinophil cationic protein(ECP)and pulmonary surfactant protein D(SP-D)on the first day before and after surgery were also compared.Results At T2,partial pressure of carbon dioxide(PaCO2)levels increased in both groups,and the degree of increase in the observation group was significantly lower than that in the control group(P＜0.05).In the observation group,partial pressure of oxygen(PaO2)levels at T2 were higher than those at T1,while PaO2 levels decreased in the control group.And PaO2 levels in the observation group were significantly higher than those in the control group at T2(P＜0.05).Compared with T1,arterial oxygen saturation(SaO2)levels in the observation group significantly increased at T2,while there was no significant change in the control group.SaO2 levels in the observation group were significantly higher than those in the control group at T1 and T2(P＜0.05).On the first day after surgery,compared with before surgery,the serum IL-6 levels in both groups decreased on average,with the observation group showing the more significant decrease.The levels of serum ECP and SP-D increased on the first day after surgery,and their levels in the observation group were significantly higher than those in the control group(P＜0.05).The postoperative anesthesia recovery time,extubation time,and anesthesia recovery room stay time in the observation group were all shorter than those in the control group(P＜0.01).Conclusion Inhalation of nebulized budesonide during surgery in elderly rectal cancer patients can effectively improve respiratory function,reduce inflammatory response,increase the levels of lung protective factors,and shorten anesthesia recovery time.
laparoscopic surgeryrectal cancerelderlybudesonidenebulization inhalationrespiratory function
万方数据
维普
