Clinical study on the treatment of refractory gastroesophageal reflux disease of stagnation-heat in liver and stomach type with Tiao-gan Li-pi method
Objective To observe the effect of Tiao-gan Li-pi method in the treatment of refractory gastroesophageal reflux disease(RGERD)of stagnation-heat in liver and stomach type.Methods A total of 60 patients with RGERD of stagnation-heat in liver and stomach type admitted to Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from March 2022 to September 2023 were selected and randomly divided into the treatment group and the control group,with 30 cases in each group.The control group was treated with omeprazole enteric coated capsules+Tiao-gan Li-pi Formula Chinese medicine granules simulant agent,while the treatment group was treated with Tiao-gan Li-pi Formula Chinese medicine granules+omeprazole enteric coated capsules.The improvement of esophageal mucosal inflammation before and after treatment,Short-Form-36 Health Survey(SF-36)and Gastroesophageal Reflux Disease Questionnaire(GERD-Q),efficacy evaluation of symptoms and syndromes,recurrence rate,and incidence of adverse reactions were compared.Results After treatment,the effective rate of improving esophageal mucosal inflammation under gastroscopy in the treatment group(93.33％)was higher than that in the control group(73.33％)(P＜0.05).After treatment,the SF-36 score of two groups significantly increased,while the GERD-Q score significantly decreased;And the SF-36 score in the treatment group was higher than that in control group,while the GERD-Q score was lower than that in the control group(P＜0.05).After treatment,the traditional Chinese medicine(TCM)syndromes scores in the treatment group were significantly lower than those in the control group,and the treatment rate of TCM syndromes in treatment group(96.67％)was higher than that in the control group(80.00％)(P＜0.05).After treatment,the clinical efficacy in the treatment group(93.33％)was higher than that in the control group(73.33％)(P＜0.05).After 6 months of follow-up,the number of patients who did not take medicine in the treatment group was significantly higher than that in the control group(P＜0.05).There was no statiscally significant difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion Tiao-gan Li-pi method can significantly improve esophageal mucosal inflammation,enhance quality of life,improve TCM syndromes and clinical symptoms,and reduce recurrence in patients with RGERD of stagnation-heat in liver and stomach type.This therapy has good clinical therapeutic effect.
Tiao-gan Li-pi methodstagnation-heat in liver and stomachrefractory gastroesophageal reflux diseasetherapeutic effectsafety
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