Diagnostic significance of serum hypoxia-inducible factor 1α and surfactant associated protein D in childhood cough variant asthma
Objective To explore the diagnostic significance of serum hypoxia-inducible factor 1α(HIF-1α)and surfactant associated protein D(SP-D)in childhood cough variant asthma(CVA).Methods A total of 80 children with CVA admitted to Hainan Modern Women and Children's Hospital from January 2020 to December 2021 were selected as the reseach subjects,and 80 children who underwent health examinations during the same period were selected as the control group.The serum levels of HIF-1α and SP-D of the children were measured by enzyme-linked immunosorbent assay,and the pulmonary ventilation function of the children was also measured.Results Compared with the control group,the serum levels of HIF-1α and SP-D in the CVA group increased(P＜0.05).Forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)in the CVA group were lower than those in the control group.There was no significant correlation between HIF-1α and SP-D levels and FVC,FEV1 and FEV1/FVC in the CVA group.Conclusion The serum levels of HIF-1α and SP-D can be used as auxiliary indicators for the diagnosis of childhood CVA.
childrencough variant asthmahypoxia-inducible factor 1αsurfactant associated protein D
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