摘要
目的 基于"痰瘀同治"理论,运用痰瘀同调方治疗超重/肥胖糖耐量异常人群,评价痰瘀同调方治疗超重/肥胖糖耐量异常人群的临床有效性及安全性.方法 选择超重/肥胖糖耐量异常痰湿瘀滞证患者72例,随机分为对照组与治疗组,各36例,对照组予基础治疗,治疗组在对照组基础上联合痰瘀同调方治疗.治疗3个月后观察2组体质量指数(BMI)、腰围(WC)、腰臀比(WHR)、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAlc)、空腹血清胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)、血脂以及中医痰湿瘀滞症状积分等指标变化,客观评价痰瘀同调方的临床疗效.结果 治疗组治疗后BMI、WC、WHR、FPG、2 h PG、HbAlc、FINS、HOMA-IR、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C),均较治疗前有明显改善,且改善程度均优于对照组(P＜0.05);治疗组治疗后改善患者形体肥胖、腹部增大、脘腹胀满、倦怠乏力、胸闷、便溏、口淡无味或黏腻等中医症状方面均优于对照组(P＜0.05);治疗组中医证候综合疗效总有效率明显高于对照组(P＜0.05).2组研究过程中均未出现不良事件.结论 痰瘀同调方干预治疗超重/肥胖糖耐量异常效果明显,安全性良好.
Abstract
Objective To evaluate the clinical efficacy and safety of synchronically regulating phlegm and blood stasis prescription in the treatment of impaired glucose tolerance in overweight/obesity individuals based on the theory of"synchronically treating phlegm and blood stasis".Methods 72 overweight/obesity patients with impaired glucose tolerance and syndrome of stagnation and congelation of phlegm-damp were selected and randomly divided into the control group and the treatment group,with 36 cases in each group.The control group received basic treatment,and the treatment group received combined treatment with synchronically regulating phlegm and blood stasis prescription on the basis of the treatment of the control group.After 3 months of treatment,the changes of body mass index(BMI),waist circumference(WC),waist-hip ratio(WHR),the levels of fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbAlc),fasting insulin(FINS)and blood lipids,and homeostasis model assessment-insulin resistance(HOMA-IR),and traditonal Chinese medicine(TCM)stagnation and congelation of phlegm-damp symptom score in two groups were observed.The clinical efficacy of synchronically regulating phlegm and blood stasis prescription was evaluated objectively.Results After treatment,compared with before treatment,BMI,WC,WHR,the levels of FPG,2hPG,HbAlc and FINS,HOMA-IR,and the levels of triglyceride(TG)and high density lipoprotein cholesterol(HDL-C)in the treatment group were significantly improved,and the improvement degree in the treatment group was better than that in the control group(P＜0.05).After treatment,compared with the control group,the treatment group showed better improvement in TCM symptoms such as physical obesity,abdominal enlargement,amassment disease of epigastrium and abdomen,fatigue,chest tightness,loose stool,and tastelessness in mouth or sticky and greasy in mouth(P＜0.05).After treatment,the total effective rate of TCM syndromes in the treatment group was significantly higher than that in the control group(P＜0.05).During the research process,no adverse events occurred in two groups.Conclusion Synchronically regulating phlegm and blood stasis prescription has the significant effect in the treatment of impaired glucose tolerance in overweight/obesity individuals.And this therapy has good safety.
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