Prospective randomized controlled study on different surgical procedures for treating rectal cancer
Objective To explore the therapeutic efficacy of endoscopic submucosal dissection(ESD)and transanal endoscopic microsurgery(TEM)in the treatment of rectal cancer(RC).Methods 88 patients with RC were selected and divided into group A(43 cases)and group B(45 cases)according to random number table method.Group A received TEM,while group B received ESD.Both groups were followed up for 6 months after surgery.Results At 6 months after surgery,the total effective rate of group B was higher than that of group A(P＜0.05).The amount of intraopeative bleeding in group B was higher than that in group A,and the average length of hospital stay and surgery time were shorter than those in group A(P＜0.05).The usage rate of antibiotics in group B was lower than that in group A(P＜0.05).During the follow-up period,there were no statistically significant diffrences in the complete tumor resection rate,tumor residual rate,recurrence rate,and incidence of complications between two groups(P＞0.05).Compared with before surgery,at 7 days after surgery,levels of serum vascular endothelial growth factor B(VEGFB),motilin,vascular endothelial growth factor A(VEGFA),chromogranin A(CgA),and vascular endothelial growth factor C(VEGFC),decreased in both groups,and group B was lower than group A;The levels of serum D-(-)-Lactic acid(DLA)all increased,and group B was higher than group A(P＜0.05).Conclusion ESD and TEM have good clinical efficacy and safety in the treatment of RC,and appropriate surgical procedures can be selected based on the specific situation of patients in clinical practice.
万方数据
维普
