Observation on the clinical therapeutic effect of ulastatin combined with octreotide in the treatment of neonatal necrotizing enterocolitis
Objective To explore the clinical therapeutic effect of ulastatin combined with octreotide in the treatment of neonatal necrotizing enterocolitis(NEC).Methods 89 cases with NEC were enrolled and divided into the control group(n=45)and the observation group(n=44)according to random number table method.The control group was treated with octreotide,and the observation group was treated with octreotide combined with ulastatin.The improvement of clinical symptoms between two groups was compared.Intestinal flora abundance and levels of inflammatory factor indicators[C-reactive protein(CRP),interleukin-6(IL-6),and interleukin-8(IL-8)]in two groups were detected.The values of cellular immune function indicators(CD4+,CD8+,and CD4+/CD8+)in two groups were measured.The occurrence of adverse reactions between two groups was compared.Results The improvement of clinical symptoms in the observation group was better than that in the control group(P＜0.05).Abundance of intestinal flora in two groups after treatment was higher than that before treatmtent,and the observation group was higher than the control group(P＜0.05).The levels of the inflammatory factor indicators in two groups after treatment were lower than those before treatment,and the observation group was lower than the control group(P＜0.05).After treatment,compared with before treatment,the values of CD4+and CD4+/CD8+indicators were higher in both groups,while the value of CD8+indicator was lower.The improvement of immune function indicators in the observation group was better than that in the control group(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between two groups(P＞0.05).Conclusion The combination of ulastatin and octreotide in the treatment of NEC can improve clinical symptoms,intestinal flora imbalance,the levels of inflammatory factors,and immune function in children.This therapy has good safety.
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