长春中医药大学学报2024，Vol.40Issue(9) ：986-989.DOI:10.13463/j.cnki.cczyy.2024.09.010

中药灌肠联合塌渍法对慢性肾衰瘙痒指数、肾功能指标的影响

Effect of Chinese herbal enema combined with external medicinal liquid application on itching index and renal function indicators in patients with chronic renal failure

徐毅 周波 罗斗前 陈方明 宋小丽
长春中医药大学学报2024，Vol.40Issue(9) ：986-989.DOI:10.13463/j.cnki.cczyy.2024.09.010
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  • 维普
  • 万方数据

中药灌肠联合塌渍法对慢性肾衰瘙痒指数、肾功能指标的影响

Effect of Chinese herbal enema combined with external medicinal liquid application on itching index and renal function indicators in patients with chronic renal failure

徐毅 1周波 1罗斗前 2陈方明 1宋小丽1
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作者信息

  • 1. 达州市中西医结合医院肾内科,四川 达州 635000
  • 2. 达州市万源市中医院肾内科,四川 达州 635000
  • 折叠

摘要

目的 探讨中药灌肠联合中药塌渍法在慢性肾衰竭(CKD3～5 期)、皮肤瘙痒(血虚风湿瘀毒证)的临床有效性及安全性.方法 本研究采用多中心、随机对照原则,共纳入病例 90 例,疗程 4 周.根据随机表法分为对照组和试验组,各 45 例.对照组维持西医基础治疗,试验组为西医基础治疗加中药灌肠联合中药塌渍法治疗.观察 2 组治疗前后皮肤瘙痒情况、肾功能、睡眠质量,以及血常规、谷丙转氨酶、钙磷、甲状旁腺激素等指标,评估临床疗效和安全性.结果 试验组总有效率为 88.8%.对照组总有效率为 44.4%.治疗后试验组血红蛋白、血肌酐、尿素氮、β2 微球蛋白、血磷指标改善明显.2 组未出现血小板、谷丙转氨酶、血钙等安全性指标异常.结论 中药灌肠联合中药塌渍法治疗慢性肾衰竭患者皮肤瘙痒的治疗方法有效,安全性好,能有效改善患者皮肤瘙痒及肾功能.

Abstract

Objective To explore the clinical efficacy and safety of Chinese herbal enema combined with external medicinal liquid application on itch of skin(blood deficiency,rheumatism,syndrome of stasis toxin)in patients with chronic renal failure(CRF 3-5 stage).Methods This study adopted the multicenter,randomized controlled trial principle.A total of 90 cases were enrolled,and the treatment course was 4 weeks for all cases.The selected patients were divided into the control group and the experiment group according to random number table method,with 45 cases in each group.The control group received basic Western medicine treatment,and the experiment group received basic Western medicine treatment plus Chinese herbal enema combined with external medicinal liquid application.The effects of itch of skin,renal function,and sleep quality before and after treatment in two groups were observed,and the levels of indicators such as blood routine,alanine aminotransferase,calcium phosphate,and parathuyroid hormone were observed.Clinical efficacy and safety were evaluated.Results The total effective rate of the experiment group was 88.8%,while that of the control group was 44.4%.After treatment,the levels of hemoglobin,creatinine,urea nitrogen,β2 microglobulin and phosphorus in the experiment group were significantly improved.There were no abnormlities in safety indicators such as platelets,glutamic-pyruvic transaminase and blood calcium in both groups.Conclusion Herbal enema combined with external medicinal liquid application is effective and safe in the treatment of itch of skin in patients with chronic renal failure,and can effectively improve pruritus and renal function in patients.

关键词

中药灌肠/中药塌渍法/慢性肾功能衰竭/皮肤瘙痒/临床研究

Key words

Chinese herbal enema/external medicinal liquid application/chronic renal failure/itch of skin/clinical research

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基金项目

四川省中医药管理局课题(2020LC0105)

出版年

2024
长春中医药大学学报
长春中医药大学

长春中医药大学学报

CSTPCD
影响因子：0.916
ISSN：1007-4813
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