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隆突性皮肤纤维肉瘤的诊断及治疗进展

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隆突性皮肤纤维肉瘤(DFSP)是一种罕见且具有侵袭性的软组织肉瘤,起源于皮肤的真皮层.生长缓慢,转移潜能低,常侵袭皮下组织,甚至可达肌肉.尽管DFSP罕见,其高复发率仍是对临床的重大挑战.目前组织病理学诊断仍是DFSP的重要确诊手段.首选治疗方式为外科手术治疗,慢Mohs显微外科手术(sMMS)通过精确切除肿瘤组织而保留健康组织,改变了DFSP的手术方式.新兴疗法如靶向治疗、免疫治疗和基因治疗也显示出巨大潜力.现对DFSP规范化诊疗方案及最新治疗研究进行阐述,以期待为患者带来更好的治疗方案.
Progress in the diagnosis and treatment of dermatofibrosarcoma protuberans
Dermatofibrosarcoma protuberans(DFSP)is a rare and aggressive soft tissue sarcoma that originates in the dermis of the skin.Characterized by slow growth and low metastatic potential,DFSP often invades subcutaneous tissues,and can even reach the muscles.Although DFSP is rare,its high recurrence rate remains a major challenge for clinical practice.Histopathological diagnosis is still an important diagnostic method for DFSP.The first treatment method chosen is surgical treatment.Slow Mohs micrographic surgery(sMMS)changes the surgical approach of DFSP by accurately excising tumor tissue while conserving healthy tissue.Emerging treatments such as targeted therapy,immunotherapy,and gene therapy have also shown great potential.This review elaborates on the standardized diagnosis and treatment plan for DFSP and the latest treatment research,in order to provide better treatment options for the patients.

dermatofibrosarcoma protuberansetiologydiagnosissurgical treatmentemerging therapies

于威、赵晨皓、李博、尚东梅

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吉林大学中日联谊医院胃肠结直肠外科,长春 130033

吉林大学中日联谊医院门急诊部,长春 130033

隆突性皮肤纤维肉瘤 病因 诊断 手术治疗 新兴疗法

吉林省科技厅自然科学基金

20210101291JC

2024

长春中医药大学学报
长春中医药大学

长春中医药大学学报

CSTPCD
影响因子:0.916
ISSN:1007-4813
年,卷(期):2024.40(9)