Clinical efficacy of regulating Ren and Du channel acupuncture therapy combined with Montelukast sodium in the treatment of cough variant asthma
Objective To ecplore the clinical efficacy of regulating Ren and Du channel acupuncture therapy combined with Montelukast sodium in the treatment of cough variant asthma and its effects on the levels of serum Toll-like receptor 4(TLR4),eosinophilic chemotactic factor(Eotaxin)and soluble growth stimulation expression gene 2(sST-2).Methods A total of 94 patients with cough variant asthma were selected and randomly divided into the control group and the observation group,with 47 cases in each group.The control group received treatment with Montelukast sodium,while the observation group received regulating Ren and Du channel acupuncture therapy on the basis of the treatment of the control group.Both groups were treated continously for 8 weeks.The clinical efficacy,pulmonary function,immune function,levels of inflammatory factors,serum levels ofTLR4,Eotaxin and sST-2,and the occurrence of adverse reactions between two groups were compared.Results The total clinical effective rate in the observation group(93.62％,44/47)was higher than that in the control group(76.60％,36/47)(P＜0.05).After treatment,the forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),and FEV1/FVC of both groups were higher than those before treatment,and the peak expiratory flow(PEF)mutation rate was lower than that before treatment,and the observation group was better than the control group(P＜0.05).After treatment,the levels of CD3+and CD4+in both groups were higher than those before treatment,and the level of CD8+was lower than that before treatment,and the observation group was better than the control group(P＜0.05).After treatment,the levels of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α)in both groups were lower than those before treatment,and the observation group was lower than the control group(P＜0.05).After treatment,the levels of TLR4,Eotaxin,and sST-2 in both groups were lower than those before treatment,and the observation group was lower than the control group(P＜0.05).Conclusion Regulating Ren and Du channel acupuncture therapy combined with Montelukast sodium in the treatment of cough variant asthma can significantly improve lung function,enhance immunity,inhibit inflammatory response,and reduce serum levels of TLR4,Eotaxin,sST-2.It is worthy of clinical promotion and application.
regulating Ren and Du channel acupuncture therapyMontelukast sodiumcough variant asthmaToll-like receptor 4eosinophilic chemotactic factorsoluble growth stimulation expressed gene 2
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维普
