Effect of modified Liujunzi decoction on the pathological status of gastric mucosa and cellular immunity in the patients with chronic atrophic gastritis
Objective To explore the effect of modified Liujunzi decoction on the pathological status of gastric mucosa and cellular immunity in the patients with chronic atrophic gastritis.Methods 106 patients with chronic atrophic gastritis were selected as the research objects and randomly divided into the control group and the observation group,with 53 cases in each group.The control group was treated with rabeprazole sodium enteric-coated capsules,hydrotalcite chewable tablets and bismuth potassium citrate capsules,and the observation group was treated with modified Liujunzi decoction on the basis of the treatment of the control group.Both groups were treated for 3 months.The clinical efficacy after 3 months of treatment,scores of traditional Chinese medicine(TCM)syndrome,pathological status of gastric mucosa,inflammatory indexes,cellular immune function indexes before treatment and after 3 months of treatment,and incidence of adverse reactions during treatment were compared between two groups.Results After 3 months of treatment,the total clinical effective rate of the observation group(94.34％,50/53)was higher than that of the control group(79.25％,42/53)(P＜0.05).Compared with before treatment,after 3 months of treatment,the epigastric pain or distention and fullness,belching and acid regurgitation,fatigue,poor appetite,intestinal metaplasia,atrophy,activity,chronic inflammation score,and the levels of serum interleukin-1 β(IL-1 β),interleukin-6(IL-6),interleukin-8(IL-8),and whole blood CD8+decreased in both groups(P＜0.05),and the observation group was lower than the control group(P＜0.05).The levels of whole blood CD3+,CD4+,and CD4+/CD8+increased in both groups(P＜0.05),and the observation group was higher than the control group(P＜0.05).During treatment,there were no adverse reactions such as abnormal liver and kidney function and vital signs in both groups.Conclusion Modified Liujunzi decoction can significantly improve TCM syndrome score,pathological status of gastric mucosa,inflammatory reaction and cellular immune function of patients with chronic atrophic gastritis,and enhance clinical efficacy.This therapy has good safety.
万方数据
维普
