Application of different doses of butorphanol in laparoscopic gynecological surgery
Objective To explore the effects of different doses of butorphanol on postoperative sedation and analgesia,quality of recovery period and stress response in patients undergoing laparoscopic gynecological surgery.Methods A total of 96 patients undergoing laparoscopic gynecological surgery were selected and divided into Group A,Group B and Group C according to random number table method,with 32 cases in each group.At 15 minutes before surgery,Group A was treated with 10 μg·kg-1 butorphanol,Group B was treated with 20 μg·kg-1 butorphanol,and Group C was treated with 30 μg·kg-1 butorphanol.All three groups were followed up until 24 hours after surgery.The quality of recovery period,sedation and analgesia effects at 2,6,12 and 24 hours after surgery,stress response before surgery and 24 hours after surgery,and the incidence of adverse reactions during the first 24 hours after surgery of three groups were compared.Results The recovery time,extubation time and stay time in post-anesthesia care unit(PACU)in Group C were longer than those in Group A and Group B(P＜0.05).The Numeric Rating Scale(NRS)scores of resting state and activity state in three groups showed the increasing trend at 2,6 and 12 hours after surgery,the NRS scores of resting state and activity state at 24 hours after surgery were higher than those at 2 and 6 hours after surgery,but lower than those at 12 hours after surgery(P＜0.05).At 12 and 24 hours after surgery,NRS scores of resting state in Group B and Group C were lower than those in Group A(P＜0.05).At 6,12 and 24 hours after surgery,the NRS scores of activity state in Group B and Group C were lower than those in Group A(P＜0.05).There was no statistically significant difference in scores of Ramsay sedation at multiple postoperative time points between two groups,all scores were above 2 points(P＞0.05).Compared with before surgery,the serum levels of cortisol(Cor),norepinephrine(NE)and blood glucose(BG)at 24 hours after surgery increased,and Group B and Group C were lower than Group A(P＜0.05).During treatment,the incidence of adverse reactions in Group C was higher than that in Group B and Group A(P＜0.05).Conclusion 20 μg·kg-1 butorphanol has good effect on postoperative sedation and analgesia in the patients undergoing laparoscopic gynecological surgery,without affecting the quality of recovery period,can relieve stress response,has high safety,and has application value.
万方数据
维普
