Study on the effect of Chaiqi Ningshen Anmian Decoction combined with Yi Mian Pillow on perimenopausal insomnia
Objective To explore the clinical treatment and mechanism analysis of Chaiqi Ningshen Anmian Decoction combined with traditional Chinese medicine Yi Mian Pillow on sleep quality in women with perimenopausal insomnia.Methods A total of 90 female patients with perimenopausal insomnia were selected and divided into Group A,Group B and Group C according to the Excel-based random grouping method,with 30 cases in each group.Group A was treated with Estazolam tablets,Group B was treated with Estazolam tablets combined with Chaiqi Ningshen Anmian Decoction,and Group C was treated with traditional Chinese medicine Yi Mian Pillow on the basis of the treatment of Group B.All three groups were treated for 4 weeks.The clinical efficacy,sleep quality,the levels of sleep structure related indexes,traditional Chinese medicine symptom score,the levels of C-reactive protein(CRP),interleukin-1β(IL-1β),5-hydroxytryptamine(5-HT)and glucose-serum albumin(GA)of each group before and after treatment were compared,and the occurrence of adverse reactions was observed.Results The total effective rate of Group A was 73.33%(22/30),Group B was 90.00%(27/30)and Group C was 96.67%(29/30).The total effective rate in Group C was significantly higher than that in Group A(P<0.05).After treatment,Pittsburgh Sleep Quality Index(PSQI)score,traditional Chinese medicine syndrome score,serum CPR and IL-1β levels all decreased,with Group C<Group B<Group A(all P<0.05).After treatment,total time in bed(TIB),actual sleep time(AST),total sleep time(TST),and the levels of serum GA and 5-HT all increased,with group C>group B>group A(all P<0.05).Conclusion On the basis of the treatment of conventional Western medicine,Chaiqi Ningshen Anmian Decoction combined with traditional Chinese medicine Yi Mian Pillow is used to treat perimenopausal insomnia.Its mechanism of action may be by regulating the levels of GA,5-HT and related inflammatory factors,inhibiting the central nervous excitability,thereby improving the sleep symptoms,sleep quality,and sleep structure of patients.
Chaiqi Ningshen Anmian Decoctiontraditional Chinese medicine Yi Mian Pillowperimenopausal insomnia
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