Clinical study on the treatment of type 2 diabetes complicated with hyperuricemia with syndrome of heat stagnation in liver and stomach with Kaiyu Qingre Formula and benzbromarone tablets
Objective To explore the clinical effect of Kaiyu Qingre Formula combined with benzbromarone tablets in the treatment of type 2 diabetes with hyperuricemia with syndrome of heat stagnation in liver and stomach.Methods 80 patients with type 2 diabetes with hyperuricemia with syndrome of heat stagnation in liver and stomach were selected and divided into the control group and the observation group,with 40 cases in each group.The control group received oral treatment with benzbromarone tablets on the basis of health education and hypoglycemic treatment,while the observation group received oral treatment with Kaiyu Qingre Formula on the basis of the treatment of the control group.Both groups were treated for 8 weeks.The traditional Chinese medicine(TCM)syndrome scores,blood glucose indicators,blood lipid indicators[total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG)],and blood uric acid(UA)levels were compared between two groups.The clinical efficacy and incidence of adverse drug reactions were also compared.Results After treatment,the scores of amassment disease of epigastrium and abdomen and distention and fullness,obesity,fullness and discomfort in chest and hypochondrium,irritability,dry mouth and bitter taste,dry stool,and the levels of fasting blood glucose,2-hour postprandial blood glucose,glycated heamoglobin A1c(HbAlc),HOMA-IR,TC,LDL-C,TG and UA were significantly reduced in both groups(P<0.05),and the observation group was lower than the control group(P<0.05);The total effective rate in the observation group(92.5%,37/40)was higher than that in the control group(65.0%,26/40)(P<0.05);No significant adverse drug reactions occurred during the treatment period in both groups.Conclusion Kaiyu Qingre Formula combined with conventional Western medicine treatment can effectively reduce the levels of blood sugar,blood lipids and UC in type 2 diabetes patients with hyperuricemia with syndrome of heat stagnation in liver and stomach,regulate the disorder of glucose and lipid metabolism in patients,and promote the alleviation of clinical symptoms.
Kaiyu Qingre Formulatype 2 diabeteshyperuricemiasyndrome of heat stagnation in liver and stomach
万方数据
维普
