Comparison of the shallow sedative effects of dexmedetomidine and remazolam besylate using bispectral index combined with electroencephalogram spectrum
Objective To explore the effects of remazolam besylate and dexmedetomidine on shallow sedation of patients with mechanical ventilation in intensive care unit through subjective and objective monitoring of analgesia and sedation,in order to promote the implementation of precise and effective analgesic and sedative strategies in clinical practice.Methods 60 patients who were admitted to the intensive care unit of the First Affiliated Hospital of Henan University of Science and Technology for mechanical ventilation treatment for more than 24 hours from January 2024 to May 2024 were selected and divided into the observation group and the control group according to random number table method,with 30 cases in each group.Both groups received remifentanil for analgesia.The observation group received remazolam besylate for sedation,while The control group received dexmedetomidine for sedation.Baseline data,Richmond Agitation and Sedation Scale(RASS)scores,relative band power(RBP),95%spectral edge frequency(SEF),and the percentage of time spent using rescue sedative drugs were compared between two groups.Results The shallow sedation rate achieved by RASS scores in both groups was 67.4%;The δ wave,θ wave,α wave,and β wave on both sides of two groups showed a decreasing trend in sequence.The RBP of δ and θ waves in the control group was higher than that in the observation group(P<0.05).The RBP of α and δ waves in the control group was higher than that in the observation group,and there was statistically significant difference(P<0.05).The 95%SEF on both sides of the observation group was higher than that of the control group(P<0.05).The percentage of time spent using rescue sedative drugs in the control group(4.91%)was higher than that in the observation group(2.81%).Conclusion Quantitative electroencephalogram can help intensive care staffoptimize the dosage of sedative drugs for different pharmacogenomic individuals,providing theoretical guidance for the development of sedative and analgesic therapy for patients with mechanical ventilation in clinical practice.
万方数据
维普
