Expression and correlation analysis of nuclear factor E2 related factor 2,lipoxin A4 and transforming growth factor-β in pleural fibrosis of tuberculous pleurisy
Objective To investigate the expression and correlation of nuclear factor E2 related factor 2(Nrf2),lipoxin A4(LXA4),and transforming growth factor-β(TGF-β)in tuberculous pleurisy(TBP)with pleural fibrosis.Methods 80 patients with TBP admitted to Shandong Provincial Public Health Clinical Centre from June 2021 to June 2023 were selected and divided into the control group and the study group(TBP with pleural fibrosis)according to whether they had combined pleural fibrosis,and were divided into mild,moderate,and severe pulmonary dysfunction groups according to their lung function.Results The levels of serum Nrf2,LXA4 and TGF-β,and pleural thickness in the study group were significantly higher than those in the control group(P<0.05),and the forced expiratory volume in one second(FEV1),forced vital capcacity(FVC)and FEV1/FVC were significantly lower than those in the control group(P<0.05).The serum levels of Nrf2,LXA4,TGF-β,and pleural thickness in the mild,moderate,and severe pulmonary dysfunction groups increased sequentially(P<0.05).Pearson correlation analysis showed that serum Nrf2,LXA4,and TGF-β levels were all correlated with FEV1,FVC,and FEV1/FVC,and pleural thickness(P<0.05).Multivariate logistic regression analysis showed that Nrf2,LXA4,and TGF-β levels were the risk factors affecting TBP with pleural fibrosis(P<0.05).Receiver operating characteristic curve(ROC curve)analysis showed that the area under the curve(AUC)of the combined diagnosis of TBP with pleural fibrosis by Nrf2,LXA4,and TGF-β was 0.934,and the combination of the three was superior to their respective individual diagnosis(all P<0.05).Conclusion The levels of serum Nrf2,LXA4,and TGF-β are significantly elevated in TBP patients,which is related to lung function and pleural thickness.Combined detection can improve the diagnostic value of TBP with pleural fibrosis.
nuclear factor E2 related factor 2lipoxin A4transforming growth factor-βtuberculous pleurisyrelevance
万方数据
维普
