Value of magnetic resonance imaging-proton density fat fraction in predicting osteoporotic vertebral fractures
Objective To explore the value of proton density fat fraction(PDFF)in IDEAL-IQ technology for predicting osteoporotic vertebral compression fracture(OVCF).Methods A total of 82 patients who underwent dual-energy X-ray absorptiometry(DXA),lumbar magnetic resonance imaging(MRI)routine examination,and IDEAL-IQ examination were collected and divided into the fracture group(n=30)and the non-fracture group(n=52).The mean difference in gender,age,height,weight,body mass index(BMI),BMD and FF between two groups was compared.Pearson correlation analysis was used to evaluate the correlation between FF mean value and BMD and age.Binary Logistic regression equation was constructed to analyze the influencing factors of OVCF with the dichotomous variable of whether osteoporotic vertebral fracture occurred as covariate.Receiver operating characteristic curve(ROC curve)was used to evaluate the diagnostic efficacy of FF alone and the combination of FF and BMD for OVCF.Results The mean value of FF,and age in the fracture group were higher than those in the non-fracture group,and BMD in the fracture group was lower than that in the non-fracture group(P<0.05).FF was negatively correlated with BMD(r=-0.488,P<0.05),and positively correlated with age(r=0.508,P<0.05).Binary Logistic regression showed that mean value of FF was a risk factor for OVCF(OR=1.247,P<0.05),and BMD was a protective factor for OVCF(OR=0.013,P<0.05).The area under the curve(AUC)of OVCF evaluated by mean value of FF was 0.778(P<0.05),with 95%CI(0.670-0.886),the sensitivity of 83.3%,and the specificity of 57.7%.The AUC of vertebral fracture determined by mean value of FF combined with BMD was 0.877(P<0.05),with 95%CI(0.805-0.948),the sensitivity of 93.3%,and the specificity of 66.4%.Conclusion PDFF is a nonradiative tool for assessing bone fragility,and it is expected to be a non-invasive biological index of bone marrow for assessing the risk of OVCF.
lumbar spineosteoporotic compression fracturefat fractionbone density
万方数据
维普
