Expression levels and diagnostic value of fecal calprotectin and plasma D-dimer in children with different types of henoch-sch?nlein purpura
Objective:To explore the expression levels and diagnostic value of fecal calprotectin and plasma D-dimer in children with different types of henoch-schönlein purpura(HSP).Methods:66 children with first-time onset of HSP admitted to our department from October 2019 to June 2022 were selected as the case group which was divided into abdominal type group(40 cases)and non-abdominal type group(26 cases).The non-abdominal type group was further divided into renal involvement group(10 cases)and renal non-involvement group(16 cases).50 healthy children who underwent physical examinations in our hospital during the same period were selected as control group.The levels of fecal calprotectin and plasma D-dimer in each group were compared,and their diagnostic value for HSP was analyzed using ROC curves.Results:The levels of fecal calprotectin and plasma D-dimer in the abdominal type group were higher than those in the non-abdominal type group,and they were higher in the non-abdominal type group than those in the control group(P＜0.05).The plasma D-dimer level in the renal involvement group was higher than that in the renal non-involvement group(P＜0.05).ROC curve analysis showed that the area under the curve of fecal calprotectin and plasma D-dimer for diagnosing HSP was 0.890 and 0.919,respectively.Fecal calprotectin and plasma D-dimer levels were positively correlated with the degree of abdominal involvement in children with HSP(r=0.676,0.630,P＜0.05).Conclusion:Fecal calprotectin and plasma D-dimer can serve as important biological markers for diagnosing HSP in children,and their expression levels are positively correlated with the degree abdominal involvement of HSP.
NETL
NSTL
万方数据
维普
