Relationship between preoperative serum levels of NETs and postoperative delirium in elderly patients undergoing laparoscopic resection of colorectal tumors and its predictive value
Objective:To explore the relationship between preoperative serum levels of neutrophil extracellular traps(NETs)and postoperative delirium(POD)in elderly patients undergoing laparoscopic resection of colorectal tumors and its predictive value.Methods:69 elderly patients who underwent laparoscopic resection of colorectal tumors in our hospital were selected from January to October 2023.They were divided into a delirium group(n=12)and a non-delirium group(n=57)based on whether they experienced delirium within 7 days after surgery.Baseline data and preoperative serum NETs levels were compared between the two groups.The influencing factors of POD in elderly patients undergoing laparoscopic resection of colorectal tumors were analyzed as well as the predictive value of preoperative serum NETs levels for POD.Results:Multivariate logistic regression analysis showed that elevated levels of preoperative serum NETs biomarkers including human myeloperoxidase(MPO)DNA and neutrophil elastase(NE)were independent risk factors for POD in elderly patients undergoing laparoscopic resection of colorectal tumors(P＜0.05).ROC curve analysis showed that the areas under the curve of MPO-DNA and NE for predicting POD were 0.9240 and 0.8582,respectively;the sensitivities were 83.3％and 75.0％,respectively;the specificities were 91.2％and 96.5％,respectively.Conclusion:Elevated preoperative serum NETs levels are associated with the occurrence of POD in elderly patients undergoing laparoscopic resection of colorectal tumors.It has high value in predicting POD.
NETL
NSTL
万方数据
