Correlations between lactate dehydrogenase,prealbumin,and their ratio and early chemotherapy efficacy in children with acute B-lymphoblastic leukemia
Objective:To explore the correlations between lactate dehydrogenase(LDH),prealbumin(PA),and LDH to PA ratio(LPR)and early chemotherapy efficacy in children with acute B-lymphoblastic leukemia(B-ALL).Methods:126 children with B-ALL admitted to our hospital from May 2020 to May 2022 were selected to observe the levels of LDH,PA,and LPR at the time of initial diagnosis(before chemotherapy/T0),on the third day of chemotherapy(T1),and on the 33rd day of chemotherapy(T2).According to the proportion of minimal residual disease on the 33rd day of chemotherapy,the patients were divided into a good efficacy group(n=94)and a poor efficacy group(n=32).Logistic regression was used to analyze the influencing factors of early chemotherapy efficacy.Results:The LDH and LPR of the children at Tl were lower than those at T0,and both were lower at T2 than those at T1(P＜0.05);at T2,PA was higher than that at T1(P＜0.05).The clinical risk classification of high-risk,T0-WBC≥100×109/L,and high LPR at T0 and T2 were risk factors for poor early chemotherapy efficacy in children(P＜0.05).Conclusion:After chemotherapy,LDH and LPR in children with B-ALL show a gradually decreasing trend,while PA shows a gradually increasing trend.LPR is correlated with the early chemotherapy efficacy in children.
acute B-lymphoblastic leukemialactate dehydrogenaseprealbuminLDH to PA ratiochemotherapyearly therapeutic effectcorrelation
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