Active Ingredients and Mechanism of Lemai Granules in Treatment of Angina Pectoris in Coronary Heart Disease Based on Network Pharmacology and Molecular Docking Technology
Objective:Based on network pharmacology and molecular docking technology,the material basis and mechanism of action of Lemai granules in the treatment of angina pectoris in coronary heart disease were explored.Methods:The chemical composition in-formation of Le Pulse particles was collected through TCMSP,ETCMand other databases and literature search;Active ingredient tar-gets were collected using the SwissTargetPrediction database;Disease targets are collected through databases such as GeneCards and DisGeNet;Use Venny to obtain intersection targets and draw Wayne diagrams;The DAVID database was used for biofunction annota-tion and enrichment analysis;Cytoscape software was used to construct a target network of active ingredient-angina pectoris for coro-nary heart disease and perform network topological analysis;Molecular docking verification via AutoDock.Results:There are 176 chemical components and 975 targets in 7 medicinal herb of Lemai granules,234 targets in angina pectoris in coronary heart disease,and 65 targets in diseases and components;Network pharmacology technology analyzed the main active ingredients of Lemai granules by salvianolic acid A,Albiflorin,Danshenxinkun D,Linoleic Acid,Tanshinaldehyde,Quercetin and Peoniflorin,it participates in vari-ous signaling pathways such as PI3K-Akt signaling pathway,HIF-1 signaling pathway,TNF signaling pathway and calcium signaling pathway,it acts on key targets such as IL-6,MMP-9,TNF and ICAM-1 to affect pathological processes such as inflammatory response,hypoxia response and thrombosis,The molecular docking results showed that the binding between the main components and the core target was good.Conclusion:The treatment of angina pectoris in coronary heart disease has the characteristics of multi-component,multi-target and multi-pathway,its mechanism of action is mainly related to reducing inflammatory response and inhibiting platelet ag-gregation.
Lemai granulesCoronary heart diseaseAngina pectorisNetwork pharmacologyMolecular dockinMechanism of action
万方数据
维普
