Effect of Anisodine Hydrobromide on Rats with Migraine
Objective:To study the effect of Anisodine Hydrobromide(AH)on the rats with migraine.Methods:Sixty rats were stochasti-cally divided into 6 groups including the model control group,the normal control group,the zolmitriptan control group(1.67 mg/kg),the high-dose(1.2 mg/kg),the medium-dose(0.6 mg/kg)and the low-dose group(0.3 mg/kg).The appropriate drugs were given to the higy-dose,medium-dose and low-dose group by caudal vein injectionwhile the zolmitriptan control group by intragastric administra-tion.After 3 days of administration,the rats were injected subcutaneously nitroglycerin injection 10 mg/kg body mass to establish rat model of migraine in addition to the rats of normal control group.The content of 5-hydroxytryptamine(5-HT),endothelin(ET),norep-inephrine(NE),NO in the serum and brain were determined.Results:Compared with the normal control group,the times of shaking head increased and the level of 5-HT was decreased(P<0.05)in serum and brain of the migraine model rats,the content of ET and NO increased(P<0.05)in the serum.But the content of NE didn't have significantly changes.The AH can improve the active sub-stance content of migraine rat model caused by nitroglycerin(NTG).It can increase the content of 5-HT,NE in serum and that of 5-HT,NE and ET in the brain tissue(P<0.05).Conclusion:AH have a positive effect on the rats with migraine by regulating the con-tents of the brain neurotransmitters.
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