Vitamin D receptor(VDR)is widely expressed in female reproductive organs,and vitamin D binds with VDR to regulate bone and calcium homeostasis and participate in various signaling pathways such as inflammation,cell-mediated immunity,cell cycle,and apoptosis inside the body.Vitamin D regulates follicular development,ovarian reserve,and endometrial receptivity,and vitamin D deficiency is associated with the pathological process of polycystic ovary syndrome.Vitamin D supplementation is of great significance in preventing premature ovarian failure,uterine myoma,endometriosis,and ovarian cancer.The level of vitamin D inside the body is also associated with the outcome of in vitro fertilization.Vitamin D deficiency is a major public health problem,and reasonable supple-mentation of vitamin D may help to maintain female reproductive health.
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