Correlation of soluble growth stimulation expressed gene 2 and galectin-3 with myocardial fibrosis in patients with coronary artery disease
Objective:To investigate the correlation of soluble growth stimulation expressed gene 2(sST2)and galectin-3(Gal-3)with myocardial fibrosis(MF)in patients with coronary artery disease(CAD),and to guide the evaluation of ischemic MF in clinical practice.Methods:A total of 56 patients with CAD and 31 patients without CAD who were hospitalized in our department from Septem-ber 2021 to September 2022 were enrolled as subjects,and according to the results of cardiovascular magnetic resonance-late gado-linium enhancement(CMR-LGE),the CAD group was further divided into MF(LGE positive)subgroup and non-MF(LGE negative)subgroup.General clinical data were collected from all subjects,and ELISA was used to measure the serum levels of sST2 and Gal-3.The correlation of sST2 and Gal-3 with CMR-LGE results was analyzed.Results:Compared with the non-CAD group,the CAD group had significantly higher levels of sST2 and Gal-3,blood pressure,creatinine,uric acid,interventricular septum thickness,glycosylated hemoglobin,and CAS score(P＜0.05)and significantly lower glomerular filtration rate and high-density lipoprotein(P＜0.05).Com-pared with the LGE-negative subgroup,the LGE-positive subgroup had significantly higher levels of sST2,Gal-3,and pro-B-type na-triuretic peptide(P＜0.05)and a significantly lower level of high-density lipoprotein(P＜0.05).LGE was positively correlated with sST2(rs=0.338,P=0.011),Gal-3(rs=0.428,P=0.001),and pro-B-type natriuretic peptide(rs=0.364,P=0.006)and was negatively corre-lated with high-density lipoprotein(rs=-0.339,P=0.011),and the partial correlation analysis with control variables showed that LGE was independently correlated with sST2(r=0.312,P=0.037)and Gal-3(r=0.419,P=0.004).The analysis showed that sST2 or Gal-3 used alone or in combination had a sensitivity of 65％,87％,and 70％,respectively,and a specificity of 81％,56％,and 87％,respec-tively,in detecting MF,and sST2 and Gal-3 had an optimal cut-off value of 36.01 ng/mL and 13.04 ng/mL,respectively,in predicting the presence or absence of ischemic MF.Conclusion:This study shows that sST2 and Gal-3 can be used to predict ischemic MF and are highly consistent with CMR-LGE in evaluating MF.
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