Advances in the treatment of non-arteriosclerotic cerebral small vessel disease
温田思宇 1崔梅1
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作者信息
1. 复旦大学附属华山医院神经内科,上海 200040
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摘要
脑小血管病(cerebral small vessel disease,CSVD)是导致卒中和痴呆的常见原因.而除了常见的小动脉硬化性脑小血管病,非动脉硬化性脑小血管病的防治也不容忽视,目前这类疾病尚缺乏特异的治疗药物,且机制未明、异质性较强,但临床对症治疗方面已有部分证据,在深入挖掘机制的同时也探索出潜在疗法.现旨在对该领域治疗进展予以综述.
Abstract
Cerebral small vessel disease(CSVD)is a common cause of stroke and dementia.Besides the common type of arterioscle-rotic CSVD,the prevention and treatment of non-arteriosclerotic arteriosclerotic CSVD should also be taken seriously.At present,there is still a lack of specific therapeutic drugs for such diseases due to unclear mechanisms and strong heterogeneity;however,some clini-cal evidence has been obtained for symptomatic treatment,and potential therapies are being explored alongside in-depth research on mechanisms.This article reviews the advances in treatment in this field.
关键词
脑小血管病/脑淀粉样血管病/伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病/卒中
Key words
cerebral small vessel disease/cerebral amyloid angiopathy/cerebral autosomal dominant arteriopathy with subcortical in-farcts and leukoencephalopathy/stroke
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