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多发性硬化的治疗进展

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多发性硬化(multiple sclerosis,MS)是 一种慢性中枢神经系统炎症性脱髓鞘疾病,随着人们对MS发病机制了解的深入,MS的治疗手段也在不断更新.近年来,新上市的疾病修饰治疗(disease-modifying therapy,DMT)药物层出不穷,临床研究显示出良好的疗效及安全性.治疗策略及目标也在更新.本文主要对近年来新上市的DMT药物的作用机制、疗效以及安全性进行综述,此外对治疗策略、治疗目标以及正在研发的新药也做了简要介绍,以期为临床决策的制定提供参考.
Advances in the treatment of multiple sclerosis
Multiple sclerosis(MS)is a chronic inflammatory demyelinating disease of the central nervous system.As our understanding of the pathogenesis of MS gradually deepens,the treatment methods for MS are being constantly updated.In recent years,a large num-ber of disease-modifying therapy(DMT)drugs have been introduced,and clinical studies have shown that such drugs have good effi-cacy and safety.Treatment strategies and goals are also being improved.This article mainly reviews the mechanism of action,efficacy,and safety of the DMT drugs introduced in recent years and briefly introduces treatment strategies,treatment goals,and new drugs under development,in order to provide a reference for clinical decision-making.

multiple sclerosistreatmentadvancesdisease-modifying therapy

王茜、陆正齐、李蕊

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中山大学附属第三医院神经内科,广州 510630

多发性硬化 治疗 进展 疾病修饰治疗

国家自然科学基金

81901229

2024

重庆医科大学学报
重庆医科大学

重庆医科大学学报

CSTPCD北大核心
影响因子:0.724
ISSN:0253-3626
年,卷(期):2024.49(5)
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