Clinicopathological features and prognostic factors of nodal T-follicular helper cell lymphoma,angioimmunoblastic-type
Objective:To investigate the clinicopathologic features and prognostic factors of nodal T-follicular helper cell lymphoma,angioimmunoblastic-type(nTFHL-AI).Methods:A retrospective analysis was performed for the clinical information of 63 patients with nTFHL-AI,and immunohistochemistry,in situ hybridization,and antigen receptor gene rearrangement were used to assess the clinicopathological features of nTFHL-AI.The Cox proportional hazards regression model was used to investigate prognostic factors.Re-sults:Immunostaining showed that the number of patients with dominant CD4-positive cells was significantly higher than that of pa-tients with dominant CD8-positive cells(66％vs.5％).The patients who tested positive for Epstein-Barr virus-encoded small RNA(EBER)showed a higher probability for the expression of CXCL13 compared with their EBER-negative counterparts(P=0.006).The 5-year overall survival(OS)rate and the progression-free survival(PFS)rate were 31％and 16％,respectively.The CXCL13-positive group had significantly better OS and PFS than the CXCL 13-negative group(P=0.003 and 0.040).On the contrary,positive BCL6 ex-pression was associated with worse OS and PFS(P=0.026 and 0.044),and negative EBER was also associated with worse OS and PFS(P=0.013 and 0.047).The multivariate analysis showed that nega-tive EBER was an independent negative prognostic factor for both OS and PFS(P=0.001 and 0.003).Conclusion:Positive expression of CXCL13 indicates a favorable prognosis of nTFHL-AI patients,while positive BCL6 and negative EBER are associated with poor prognosis,and negative EBER is an independent risk factor for the prognosis of patients.
万方数据
维普
